The role of hepatic fat accumulation in glucose and insulin homeostasis - dysregulation by the liver
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The role of hepatic fat accumulation in glucose and insulin homeostasis - dysregulation by the liver. / London, Amalie; Lundsgaard, Anne-Marie; Kiens, Bente; Bojsen-Møller, Kirstine Nyvold.
In: Journal of Clinical Medicine, Vol. 10, No. 3, 390, 2021.Research output: Contribution to journal › Review › Research › peer-review
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T1 - The role of hepatic fat accumulation in glucose and insulin homeostasis - dysregulation by the liver
AU - London, Amalie
AU - Lundsgaard, Anne-Marie
AU - Kiens, Bente
AU - Bojsen-Møller, Kirstine Nyvold
N1 - CURIS 2021 NEXS 038
PY - 2021
Y1 - 2021
N2 - Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes.
AB - Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes.
KW - Faculty of Science
KW - Non-alcoholic fatty liver disease (NAFLD)
KW - Glucose metabolism
KW - Insulin resistance
KW - Hepatic glucose production
KW - Hyperinsulinemic-euglycemic clamp
KW - Proton MR spectroscopy
KW - Insulin clearance
KW - Molecular regulation
U2 - 10.3390/jcm10030390
DO - 10.3390/jcm10030390
M3 - Review
C2 - 33498493
VL - 10
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
SN - 2077-0383
IS - 3
M1 - 390
ER -
ID: 255843115