Development and an initial validation of the Responses to Illness Severity Quantification (RISQ) score for severely malnourished children
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Development and an initial validation of the Responses to Illness Severity Quantification (RISQ) score for severely malnourished children. / Dale, Nancy M; Ashir, Garba Mohammed; Maryah, Lawan Bukar; Shepherd, Susan; Tomlinson, George; Briend, André; Zlotkin, Stanley; Parshuram, Christopher.
I: Acta Pædiatrica, Bind 111, Nr. 9, 2022, s. 1752-1763.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Development and an initial validation of the Responses to Illness Severity Quantification (RISQ) score for severely malnourished children
AU - Dale, Nancy M
AU - Ashir, Garba Mohammed
AU - Maryah, Lawan Bukar
AU - Shepherd, Susan
AU - Tomlinson, George
AU - Briend, André
AU - Zlotkin, Stanley
AU - Parshuram, Christopher
N1 - This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Aim: To develop and perform an initial validation of a score to measure severity of illness in hospitalized children with severe acute malnutrition (SAM).Methods: A prospective study enrolled SAM children aged 6-59 months hospitalized in Borno State, Nigeria. Candidate items associated with inpatient mortality were combined and evaluated as candidate scores. Clinical and statistical methods were used to identify a preferred score.Results: The 513 children enrolled had a mean age of 15.6 months of whom 48 (9%) died. Seven of the ten evaluated items were significantly associated with mortality. Five different candidate scores were tested. The final score, Responses to Illness Severity Quantification (RISQ), included 7 items: heart rate, respiratory rate, respiratory effort, oxygen saturation, oxygen delivery, temperature and level of consciousness. The mean RISQ score on admission was 2.6 in hospital survivors and 7.3 for children dying <48hr. RISQ scores <24hr before death had an area under the receiver operating characteristic curve (AUROC) of 0.93. The RISQ score performed similarly across differing clinical conditions with AUROCs 0.77-0.98 for all conditions except oedema.Conclusion: The RISQ score can identify high risk malnourished children at and during hospital admission. Clinical application may help prioritize care and potentially improve survival.
AB - Aim: To develop and perform an initial validation of a score to measure severity of illness in hospitalized children with severe acute malnutrition (SAM).Methods: A prospective study enrolled SAM children aged 6-59 months hospitalized in Borno State, Nigeria. Candidate items associated with inpatient mortality were combined and evaluated as candidate scores. Clinical and statistical methods were used to identify a preferred score.Results: The 513 children enrolled had a mean age of 15.6 months of whom 48 (9%) died. Seven of the ten evaluated items were significantly associated with mortality. Five different candidate scores were tested. The final score, Responses to Illness Severity Quantification (RISQ), included 7 items: heart rate, respiratory rate, respiratory effort, oxygen saturation, oxygen delivery, temperature and level of consciousness. The mean RISQ score on admission was 2.6 in hospital survivors and 7.3 for children dying <48hr. RISQ scores <24hr before death had an area under the receiver operating characteristic curve (AUROC) of 0.93. The RISQ score performed similarly across differing clinical conditions with AUROCs 0.77-0.98 for all conditions except oedema.Conclusion: The RISQ score can identify high risk malnourished children at and during hospital admission. Clinical application may help prioritize care and potentially improve survival.
KW - Faculty of Science
KW - Malnutrition
KW - Severity of illness
KW - Score
KW - Mortality
KW - Child
U2 - 10.1111/apa.16410
DO - 10.1111/apa.16410
M3 - Journal article
C2 - 35582782
VL - 111
SP - 1752
EP - 1763
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 9
ER -
ID: 307006615