Effects of exercise training intensity and duration on skeletal muscle capillarization in healthy subjects: A meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Effects of exercise training intensity and duration on skeletal muscle capillarization in healthy subjects: A meta-analysis. / Liu, Yujia; Christensen, Peter Møller; Hellsten, Ylva; Gliemann, Lasse.
I: Medicine and Science in Sports and Exercise, Bind 54, Nr. 10, 2022, s. 1714-1728.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of exercise training intensity and duration on skeletal muscle capillarization in healthy subjects: A meta-analysis
AU - Liu, Yujia
AU - Christensen, Peter Møller
AU - Hellsten, Ylva
AU - Gliemann, Lasse
N1 - Copyright © 2022 by the American College of Sports Medicine.
PY - 2022
Y1 - 2022
N2 - Purpose: This study aimed to investigate the effect of intensity and duration of continuous and interval exercise training on capillarization in skeletal muscle ofhealthy adults. Methods: PubMed and Web of Science were searched from inception to June 2021. Eligibility criteria for studies were endurance exercise training >2 wk in healthy adults, and the capillary to fiber ratio (C:F) and/or capillary density (CD) reported. Meta-analyses were performed, and subsequent subgroup analyses were conducted by the characteristics of participants and training scheme. Results: Fifty-seven trials from 38 studies were included (10%/90%, athletic/sedentary). C:F was measured in 391 subjects from 47 trials, whereas CD was measured in 428 subjects from 50 trials. Exercise training increased C:F (mean difference, 0.33 (95% confidence interval, 0.30–0.37)) with lowheterogeneity (I2 = 45.08%) and CD (mean difference, 49.8 (36.9–62.6) capillaries per millimeter squared) with moderate heterogeneity (I2 = 68.82%). Compared with low-intensity training (<50% of maximal oxygen consumption (VO˙2max)), 21% higher relative change in C:F was observed after continuous moderate-intensity training (50%–80% of VO˙2max) and 54% higher change after interval training with high intensity (80%–100% of VO˙2max) in sedentary subjects. The magnitude of capillary growth was not dependent on training intervention duration. In already trained subjects, no additional increase in capillarization was observed with various types of training. Conclusions: In sedentary subjects, continuous moderate-intensity training and interval training with high intensity lead to increases in capillarization, whereaslow-intensity training has less effect. Within the time frame studied, no effect on capillarization was established regarding training duration in sedentary subjects. The meta-analysis highlights the need for further studies in athlete groups to discern if increased capillarization can be obtained, and if so, which combination is optimal (time vs intensity).
AB - Purpose: This study aimed to investigate the effect of intensity and duration of continuous and interval exercise training on capillarization in skeletal muscle ofhealthy adults. Methods: PubMed and Web of Science were searched from inception to June 2021. Eligibility criteria for studies were endurance exercise training >2 wk in healthy adults, and the capillary to fiber ratio (C:F) and/or capillary density (CD) reported. Meta-analyses were performed, and subsequent subgroup analyses were conducted by the characteristics of participants and training scheme. Results: Fifty-seven trials from 38 studies were included (10%/90%, athletic/sedentary). C:F was measured in 391 subjects from 47 trials, whereas CD was measured in 428 subjects from 50 trials. Exercise training increased C:F (mean difference, 0.33 (95% confidence interval, 0.30–0.37)) with lowheterogeneity (I2 = 45.08%) and CD (mean difference, 49.8 (36.9–62.6) capillaries per millimeter squared) with moderate heterogeneity (I2 = 68.82%). Compared with low-intensity training (<50% of maximal oxygen consumption (VO˙2max)), 21% higher relative change in C:F was observed after continuous moderate-intensity training (50%–80% of VO˙2max) and 54% higher change after interval training with high intensity (80%–100% of VO˙2max) in sedentary subjects. The magnitude of capillary growth was not dependent on training intervention duration. In already trained subjects, no additional increase in capillarization was observed with various types of training. Conclusions: In sedentary subjects, continuous moderate-intensity training and interval training with high intensity lead to increases in capillarization, whereaslow-intensity training has less effect. Within the time frame studied, no effect on capillarization was established regarding training duration in sedentary subjects. The meta-analysis highlights the need for further studies in athlete groups to discern if increased capillarization can be obtained, and if so, which combination is optimal (time vs intensity).
KW - Faculty of Science
KW - Capillarization
KW - Exercise training
KW - Capillary to fiber ratio
KW - Capillary density
KW - Meta-analysis
U2 - 10.1249/MSS.0000000000002955
DO - 10.1249/MSS.0000000000002955
M3 - Review
C2 - 35522254
VL - 54
SP - 1714
EP - 1728
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 10
ER -
ID: 305416517