Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host
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Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host. / Nielsen, Line; Søgaard, Mette; Jensen, Trine Hammer; Andersen, Mads Klindt; Aasted, Bent; Blixenkrone-Møller, Merete.
I: Journal of General Virology, Bind 90, 2009, s. 2157-2165.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host
AU - Nielsen, Line
AU - Søgaard, Mette
AU - Jensen, Trine Hammer
AU - Andersen, Mads Klindt
AU - Aasted, Bent
AU - Blixenkrone-Møller, Merete
PY - 2009
Y1 - 2009
N2 - The mechanisms behind the in vivo virulence of immunosuppressive wild-type Morbillivirus infections are still not fully understood. To investigate lymphotropism and host responses we have selected the natural host model of canine distemper virus (CDV) infection in mink. This model displays multisystemic infection similar to measles virus (MV) and rinderpest virus (RPV) infections in their susceptible natural hosts. The wild-type CDVs investigated provoked marked virulence differences inducing mild versus marked to severe acute disease. The mildly virulent wild-type induced transient lymphopenia despite the development of massive infection of peripheral blood mononuclear cells (PBMCs) exceeding that determined for the highly virulent wild-type, indicating an inverse relationship between acute virulence and the extent of viremia between the investigated wild-types. Single-cell cytokine production in PBMCs was investigated throughout the acute infections. We observed Th1- and Th2-type cytokine responses beginning in the prodromal phase, and late inflammatory responses were shared between the wild-type infections.
AB - The mechanisms behind the in vivo virulence of immunosuppressive wild-type Morbillivirus infections are still not fully understood. To investigate lymphotropism and host responses we have selected the natural host model of canine distemper virus (CDV) infection in mink. This model displays multisystemic infection similar to measles virus (MV) and rinderpest virus (RPV) infections in their susceptible natural hosts. The wild-type CDVs investigated provoked marked virulence differences inducing mild versus marked to severe acute disease. The mildly virulent wild-type induced transient lymphopenia despite the development of massive infection of peripheral blood mononuclear cells (PBMCs) exceeding that determined for the highly virulent wild-type, indicating an inverse relationship between acute virulence and the extent of viremia between the investigated wild-types. Single-cell cytokine production in PBMCs was investigated throughout the acute infections. We observed Th1- and Th2-type cytokine responses beginning in the prodromal phase, and late inflammatory responses were shared between the wild-type infections.
KW - Former Faculty of Life Sciences
U2 - 10.1099/vir.0.010744-0
DO - 10.1099/vir.0.010744-0
M3 - Journal article
C2 - 19494053
VL - 90
SP - 2157
EP - 2165
JO - Journal of General Virology
JF - Journal of General Virology
SN - 0022-1317
ER -
ID: 13413338